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Tuesday, June 26, 2012

Nissan chief wary despite quick disaster recovery

FILE - In this March 21, 2012 file, Nissan Motor Co. Chief Executive Carlos Ghosn speaks during a news conference on the company's brand "Datsun" at its head office in Yokohama, near Tokyo. Ghosn said Tuesday, June 26, the automaker needs to conserve cash despite its quick recovery from a year of disasters as the global economic outlook is highly uncertain. Ghosn told the company's annual shareholders meeting that Nissan Motor Co. had bounced back from the earthquake and tsunami in northeastern Japan and the flooding in Thailand that battered Japanese automakers last year. Nissan, like other Japanese automakers, is also looking to growth in emerging markets such as Indonesia, India and Russia. (AP Photo/Itsuo Inouye)

In this photo taken May 29, 2012, the global headquarters of Nissan Motor Co. in Yokohama, near Tokyo is shown. Nissan Chief Executive Carlos Ghosn defended the quick recovery of the Japanese automaker from a year of disasters to record global sales Tuesday, June 26, 2012, while fielding shareholders questions about low dividends and lagging stock prices. (AP Photo/Itsuo Inouye)

YOKOHAMA, Japan (AP) ? Nissan Chief Executive Carlos Ghosn said Tuesday the automaker needs to conserve cash despite its quick recovery from a year of disasters as the global economic outlook is highly uncertain.

Ghosn told the company's annual shareholders meeting that Nissan Motor Co. had bounced back from the earthquake and tsunami in northeastern Japan and the flooding in Thailand that battered Japanese automakers last year. Nissan, like other Japanese automakers, is also looking to growth in emerging markets such as Indonesia, India and Russia.

Nissan's January-March profit more than doubled to 75.3 billion yen ($941 million). Its global sales reached a record 4.85 million vehicles for the business year ended March in a remarkable recovery from production disruptions stemming from the disasters. Nissan is expecting a 400 billion yen ($5 billion) profit for the business year through March 2013.

But a shareholder who identified herself only by her surname Takahashi demanded to know why she was getting a dividend of only 20 yen (31 cents) a share if Nissan was doing so well.

Ghosn said Nissan has less cash than Japanese rivals Toyota Motor Corp. and Honda Motor Co. and must be more prudent in the current economic situation. The U.S. economic recovery has stalled and Europe's economy is stymied by high debt and austerity measures.

"We are facing extreme volatility," he told nearly 1,200 shareholders packing a convention center in the port city of Yokohama, where Nissan is headquartered.

Ghosn also grumbled about the strong yen, which erodes the value of overseas sales for Japanese exporters like Nissan. He said he was worried Nissan might have to reduce Japan production if the government didn't do something to bring the yen's strength under control.

Nissan, which makes the Altima sedan, Infiniti luxury model and Leaf electric car, is allied with Renault SA of France.

Nissan is reviving the Datsun nameplate brand that helped it grow in the U.S. when it was still a newcomer during the 1960s, but this time for emerging markets.

Nissan is also counting on growth in China, although not at the stupendous pace of a few years ago.

"We continue to be bullish on China," Ghosn said.

___

Follow Yuri Kageyama on Twitter at http://twitter.com/yurikageyama

Associated Press

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Video: Republican Senate candidate accuses opponent of communism

Sunscreen ban leaves students severely burned

After a school sunscreen ban left two elementary students severely burned, their mother is taking on the school district. And it could happen elsewhere: 49 states have laws on the books barring schools from letting kids use sunscreen without a doctor's note.

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Fitness fitness conscious people how to do business ? Yoga Netipot ...

Posted by admin on Jun 24, 2012 in Fitness | 0 comments

Fitness fitness conscious folks how to do enterprise ? Yoga Netipot ? gifts& well being care goods

Report by hi joiney

Statistics show that China?s health equipment market is about 40 billion?? five billion yuan. At present, China has practically 500 fitness equipment makers in the globe nearly all the common sorts of fitness equipment, Chinese companies are in production, and processing a large number of foreign manufacturers, Chinese-produced fitness equipment in the international market place accounts for about 60 % share of the export trade amounted to two billion U.S. dollars.

Even so, China?s 1.three billion population, have fitness equipment in the house is much like a treadmill for 1 year about twenty million units sold, home penetration price of only one%. With the ?fitness? movement launched in depth, people?s well being awareness year by year, tv, the network adverts on fitness gear growing, then the fitness equipment industry in the end the present predicament? What type of fitness gear company a lot more rewarding it?

Lack of professional advice gear generally idle
A lot of customers are prepared to invest big bucks on the food table, but do not want to vote thousands of dollars on the buy of fitness gear, it is shoppers do not form a loved ones fitness concept of consumption. Zhejiang Province, Zhejiang Province sports activities stationery market be much more concentrated within the sporting items sales market place, but at times the client market place in the true workers also much less than the marketplace. Market on the very first floor since the sideline stationery, played a lot more than a small active on the second floor, second floor, only a handful of huge fitness equipment for sale, the remaining facade of vacant or partially sublet for the collection.

Organization users, mentioned right after the SARS crisis, a period of time is the most prosperous of fitness equipment sales, when folks abruptly realized the significance of loved ones fitness, acceptable workout can improve cardiovascular function and immunity, but this busy period fairly short. Reflected from a side, men and women weak buyer awareness of fitness gear, fitness gear eventually led to a extremely very low penetration.

, Of course, awareness of the importance of the fitness is equally important. Fitness gear to buy to enter the property only the first step is equal to consumption. Lack of effective specialist advice, with the outcome following the consumer had allow the fresh strength gear lying about, do not persevere.

In addition, the company?s advertising in the fitness gear investment is fairly modest. Fitness equipment goods to broaden the media ?exposure?, in the situation of weak buyer awareness, boost market place share is a huge increase.

A lot of makers, but the lack of neighborhood brand names
Have information on the worldwide market place much more than 60% of fitness gear are affixed with ?Produced in China?, but very couple of Chinese very own brands. The cause is that goods in the worldwide marketplace competitiveness is not higher, only for foreign businesses to do a great deal of processed products. On the one particular hand the domestic production of global common sports activities equipment, on the other hand, domestic buyers have two or three instances as significantly bogus sales of foreign brand names. This kind of embarrassment is a sign that, in the effectively-identified internationally of the nationwide brands missing.

From the manufacturing viewpoint, tiny-scale energy is not strong corporate few, and even many companies have not passed the good quality technique certification, and so on., these all reflect the brand-title sports activities manufacturing in the gaps and deficiencies in the road. Organized by the China Sporting Goods Association to carry out the fitness gear industry in China renowned brand evaluation final results show that O Reiter, a excellent family, Shu Hua, evergreen, English Pais five brand names in the influential shoppers.

Treadmill finest selling inside four,000 yuan
Property fitness gear industry and the commercial industry, the market place is divided into two blocks, domestic industry dimension business market than the massive, quickly growth, as soon as a fitness sector who strive to enlarge the cake. Items sold by home users typically little dimension, light weight, attributes easy mixture of instruments. The commercial market place sales target for the fitness centers, community sports activities centers or schools, commercial buildings and other institutions, buy is entirely functional high-grade merchandise.

Top home fitness equipment from sales of view, electric treadmill is nevertheless the most popular, the marketplace share of the complete sales of fitness gear Practically sixty percent of the market, single-keep retail sales up to 30 units a month or so. Product sales followed by multi-functional fitness equipment and workout bike, weight of close to 15% and 10%. On the contrary, rowing exercising machines, cross-nation ski machine due to use of area constraints, the reasonably large charges, product sales decline sharply.

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Monday, June 25, 2012

Boosting blood system protein complex protects against radiation toxicity

ScienceDaily (June 24, 2012) ? New research in Nature Medicine shows that boosting a protein pathway in the body's blood making system protects mice from otherwise fatal radiation poisoning.

Scientists in the multi-institutional study -- posted online by the journal on June 24 -- say their findings open the potential for new treatments against radiation toxicity during cancer treatment or environmental exposures -- such as in a nuclear explosion or accident.

By identifying a target-specific intervention to protect the hematopoietic system against radiation toxicity, the study addresses a largely unmet challenge, according to the researchers.

"These findings suggest that pharmacologic augmentation of the activity of the Thbd-aPC pathway by recombinant Thbd (thrombomodulin) or aPC (activated protein C) might offer a rational approach to the mitigation of tissue injury and lethality caused by ionizing radiation," the scientists write in their manuscript. "Recombinant human aPC has undergone extensive clinical testing in patients, and recombinant soluble human Thbd is currently being investigated for efficacy in antithrombotic therapy in humans. Our data encourage the further evaluation of these proteins for their radio-mitigating activities."

The study reveals a previously unknown function of the Thbd-aPC pathway in radiation mitigation. The pathway is normally known for its ability to prevent the formation of blood clots and help the body fight infections. The researchers found the pathway helps blood cells in the bone marrow recover from injury caused by radiation exposure. They demonstrated that pharmacologic boosting of this pathway with two drugs tested for the treatment of thrombosis or infection (recombinant Thbd and aPC respectively) can be used in mice to prevent death caused by exposure to lethal doses of radiation.

In all instances of treatment with recombinant soluble Thbd or aPC, the result was accelerated recovery of hematopoietic progenitor cell activity in bone marrow and a reduction in the harmful effects of lethal total body irradiation. When treatment was with aPC, these benefits occurred even when treatment was delayed for 24 hours.

The scientists caution their study involves early laboratory research in mice, so it remains to be tested how the findings may translate to human treatment. Researchers also need to determine exactly why the protective function of the targeted Thbd-aPC protein pathway seems to work so well in mice.

Researchers noted that the protective benefits of Thbd-aPC occurred only in vivo in irradiated mouse models. The researchers reported that overexpressed Thbd in irradiated laboratory cell cultures did not offer the same protective benefits, as the cells did not survive. This indicates the protective benefits of Thbd on blood making cells in irradiated mouse models depends on the help of additional cells or molecules in the body, which the researchers are trying to identify in a follow-up study.

The study involves extensive multi-scientist collaborations that combined previously independent lines of research by groups at Cincinnati Children's Hospital Medical Center and the University of Ulm, Germany (led by Hartmut Geiger, PhD, Division of Experimental Hematology/Cancer Biology and the Department of Dermatology/Allergic Diseases); the University of Arkansas, Little Rock (led by Martin Hauer-Jensen, MD, PhD, Division of Radiation Health, the College of Pharmacy and the Central Arkansas Veterans Healthcare System); the Blood Research Institute in Milwaukee, Wis. (led by Hartmut Weiler, PhD); and The Scripps Research Institute in La Jolla, Calif. (led by John H. Griffin, PhD, Department of Molecular and Experimental Medicine).

The research team said the current study exemplifies a global shift to multi-investigator projects that allow a combination of varied expertise by scientists tackling complex problems from the perspective of their respective fields. This approach requires the willingness of investigators to share unpublished data and engage in an open collaboration. The researchers also said the study underscores the importance of continued federal funding for leading edge basic research that can benefit human health.

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The above story is reprinted from materials provided by Cincinnati Children's Hospital Medical Center, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Hartmut Geiger, Snehalata A Pawar, Edward J Kerschen, Kalpana J Nattamai, Irene Hernandez, Hai Po H Liang, Jose ? Fern?ndez, Jose A Cancelas, Marnie A Ryan, Olga Kustikova, Axel Schambach, Qiang Fu, Junru Wang, Louis M Fink, Karl-Uwe Petersen, Daohong Zhou, John H Griffin, Christopher Baum, Hartmut Weiler & Martin Hauer-Jensen. Pharmacological targeting of the thrombomodulin?activated protein C pathway mitigates radiation toxicity. Nature Medicine, 24 June 2012 DOI: 10.1038/nm.2813

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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